270 papers
This study demonstrates that in *Xenopus laevis*, fibronectin orchestrates the assembly of the extracellular matrix and the multilayered organization of second heart field progenitor cells within the dorsal pericardial wall, thereby ensuring proper cardiac outflow tract elongation and ventricular development.
This study identifies three cooperative regulatory programs involving Trh, Vvl, and Grn that define the Drosophila airway progenitor field, linking its 2D radial pattern to 3D tubular morphogenesis through distinct mechanisms of invagination and proximo-distal patterning.
This study demonstrates that the histone methyltransferase activity of KMT2D is essential for normal lung development by regulating H3K4 methylation to control cell proliferation and differentiation, as its catalytic inactivation leads to pulmonary hypoplasia, impaired alveolar and airway formation, and expanded mesenchymal progenitor cells.
This study demonstrates that Robo receptors, particularly Robo2 and Robo1, play subtype-dependent roles in guiding zebrafish olfactory sensory neuron axons to specific protoglomeruli, with their loss leading to misrouting that is normally prevented by Slit/Robo signaling and potentially redirected by Netrin1b.
This paper introduces LUCID-org, a reproducible, cost-effective, and non-toxic light-sheet microscopy pipeline combined with machine learning that enables comprehensive 3D quantitative analysis of human brain organoid cytoarchitecture, successfully revealing structural defects in a CENPJ-mutated microcephaly model.
This study identifies Hotaru, a testis-specific endonuclease that enforces maternal mitochondrial DNA inheritance in animals by selectively recognizing and cleaving cruciform DNA structures within the paternal mitochondrial genome, thereby ensuring its elimination during spermatogenesis.
This study reveals that the non-gonadal PIWI protein Aubergine regulates regenerative stem cell proliferation and tumorigenesis in the Drosophila adult intestine by driving damage-induced protein synthesis of key factors like Myc and Sox21a, a function that operates independently of its canonical piRNA pathway role.
This study reveals that germline tumors in Drosophila ovaries inhibit the differentiation of neighboring wild-type stem cells by mimicking the stem cell niche through the secretion of reduced levels of BMP ligands, which sustain moderate signaling sufficient to repress differentiation genes.
This study reveals that ovarian cellular diversity arises from a conserved, spatially encoded program where multipotent coelomic epithelium cells are dynamically primed into distinct supporting and steroidogenic subdomains prior to ingression, establishing the lineage origins of adult ovarian cell types.
By combining live imaging and single-cell multi-omics, this study reveals that Notch inhibition selectively triggers a rare subpopulation of Deiters cells to transdifferentiate into hair cells through coordinated epigenetic and transcriptional remodeling, while the majority of supporting cells remain refractory despite similar signaling changes.
This study reveals that a previously unknown Csf1r-expressing non-lymphatic precursor lineage gives rise to approximately 60% of dermal lymphatic endothelial cells, which are essential for normal lymphatic development and the prevention of dermal edema.
This study reveals that the Drosophila ovary generates three distinct follicle waves—two adult waves and a novel pupal wave—each following unique developmental programs to support early fertility, high fecundity, and the hormonal signaling required for adult tissue maturation and behavioral rewiring.
This study demonstrates that TGFβ signaling regulates the spacing of epithelial branches in the developing lung by promoting mesenchymal cell condensation, which physically displaces adjacent branches, rather than relying on intrinsic epithelial self-avoidance mechanisms.
This study establishes optimized ex utero culture systems that support mouse embryonic development from gastrulation to the fetal period, revealing that a critical midgestational metabolic switch is intrinsically programmed within the embryo and independent of maternal or placental signals.
Using human iPSC-derived 3D trunk-like structures, this study reveals that duration-dependent TBX6 activity initiates human trunk mesoderm diversification, while downstream FOXC1/2 factors subsequently stabilize somitic identity and enable sclerotome differentiation.
This study reveals that a midgestational metabolic constraint in embryonic purine salvage pathways drives distinct, compartmentalized strategies for purine synthesis between the embryo and placenta, thereby preventing resource competition and enabling coordinated mammalian growth, while also identifying a species-specific reliance on purine salvage precursors for human placental differentiation that is absent in mice.
This study reveals that Cep57 acts as a critical molecular bridge in early vertebrate embryos, linking centrosome integrity to G1/S checkpoint control and DNA damage responses to ensure genome stability and prevent apoptosis-associated developmental defects like microcephaly.
This study demonstrates that prenatal depletion of CSF1R+ macrophages and osteoclasts via PLX5622 treatment impairs neural crest proliferation and disrupts craniofacial morphogenesis, leading to significant skeletal defects and altered cytokine signaling.
This study demonstrates that an FZD4/LRP5 agonist antibody (F4L5.13) restores pericyte coverage and vascular integrity in a model of severe pericyte deficiency by enhancing PDGFB signaling through beta-catenin-dependent pathways, offering a promising regenerative therapeutic strategy for neurovascular disorders.
This study demonstrates that Cygb-dependent NO-sGC-cGMP signaling is essential for normal ventricular morphogenesis and diastolic function during development, as its disruption in zebrafish recapitulates hypoplastic left heart syndrome features, suggesting that pharmacological activation of sGC could offer a therapeutic strategy for hypoplastic ventricular disease.